Deletion of the LTR enhancer/promoter has no impact on the integration profile of MLV vectors in human hematopoietic progenitors.
Moloney murine leukemia Calcium Magnesium virus (MLV)-derived gamma-retroviral vectors integrate preferentially near transcriptional regulatory regions in the human genome, and are associated with a significant risk of insertional gene deregulation.Self-inactivating (SIN) vectors carry a deletion of the U3 enhancer and promoter in the long terminal